2011
N-glycosylation and biological activity of recombinant human alpha1-antitrypsin expressed in a novel human neuronal cell line
Véronique Blanchard, Xi Liu, Susann Eigel, Matthias Kaup, Silke Rieck, Sabina Janciauskiene, Volker Sandig, Uwe Mark, Peter Walden, Rudolf Tauber, Markus Berger
Biotechnology and Bioengineering, Volume 108, Issue 9, pages 2118-2128, September 2011
A chemically defined production process for highly attenuated poxviruses.
Jordan I., Northoff S., Thiele M., Hartmann S., Horn D., Höwing K., Bernhardt H., Oehmke S., von Horsten H., Rebeski D., Hinrichsen L., Zelnik V., Mueller W., Sandig V.
Biologicals. 2011 Jan; 39(1): 50–8. Epub 2011 Jan 15.
PMID: 21237672 [PubMed – in process]
2010
Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysis.
Niklas J., Schräder E., Sandig V., Noll T., Heinzle E.
Bioprocess Biosyst Eng. 2010 Dec 25. [Epub ahead of print]
PMID: 21188421 [PubMed - as supplied by publisher]
Production of non-fucosylated antibodies by co-expression of heterologous GDP-6-deoxy-D-lyxo-4-hexulose reductase.
von Horsten HH, Ogorek C., Blanchard V., Demmler C., Giese C., Winkler K., Kaup M., Berger M., Jordan I., Sandig V.
Glycobiology. 2010 Dec; 20 (12):1607-18. Epub 2010 Jul 15.
PMID: 20639190 [PubMed - indexed for MEDLINE]
Prediction of cytokine release using gene expression profile analysis.
Radke L, Lopez D. A., Lubitz A., Giese C., Frohme M.
Chemistry Today. 2010, Vol. 28 n 5, Sept./Oct. 2010,
Focus on Pharmaceutical analysis
Engineering tissue alternatives to animals: applying tissue engineering to basic research and safety testing.
Holmes A., Brown R., Shakesheff K., Giese C.
Regen. Med. 2010, 4(4), 579–592
Establishment of fruit bat cells (Rousettus aegyptiacus) as a model system for the investigation of filoviral infection.
Krähling V., Dolnik O., Kolesnikova L., Schmidt-Chanasit J., Jordan I., Sandig V., Günther S., Becker S.
PLoS Negl Trop Dis. 2010 Aug 24; 4(8): e802.
PMID: 20808767 [PubMed - indexed for MEDLINE] Free PMC Article
Immunological substance testing on human lymphatic micro-organoids in vitro.
Giese C., Lubitz A., Demmler C., Reuschel J., Bergner K., Marx U.
Journal of Biotechnology 2010, Volume 148, Issue 1, 1 July 2010, Pages 38–45
2009
Cell lines from the Egyptian fruit bat are permissive for modified vaccinia Ankara.
Jordan I., Horn D., Oehmke S., Leendertz FH, Sandig V.
Virus Res. 2009 Oct; 145(1): 54-62. Epub 2009 Jun 18.
PMID: 19540275 [PubMed - indexed for MEDLINE]
New avian suspension cell lines provide production of influenza virus and MVA in serum-free media: studies on growth, metabolism and virus propagation.
Lohr V., Rath A., Genzel Y., Jordan I., Sandig V., Reichl U.
Vaccine. 2009 Aug 6; 27(36): 4975-82. Epub 2009 Jun 14.
PMID: 19531390 [PubMed – indexed for MEDLINE]
Glycan analysis in cell culture-based influenza vaccine production: influence of host cell line and virus strain on the glycosylation pattern of viral hemagglutinin.
Schwarzer J., Rapp E., Hennig R., Genzel Y., Jordan I., Sandig V., Reichl U.
Vaccine. 2009 Jul 9; 27(32): 4325-36. Epub 2009 May 14.
PMID: 19410619 [PubMed – indexed for MEDLINE]
Trends in cell culture technology.
Marx, U.
to be published in:New Technologies for Toxicity Testing, Ed.: Michael Balls,
Landes Bioscience. 2009
2008
An avian cell line designed for production of highly attenuated viruses.
Jordan I., Vos A., Beilfuss S., Neubert A., Breul S., Sandig V.
Vaccine. 2009, Jan 29; 27(5): 748–56. Epub 2008 Dec 9.
PMID: 19071186 [PubMed – indexed for MEDLINE]
Quality for Biologics
Zietze, S., Riedel, M.
Biopharm Knowledge Publishing. 2008
Standardization, evaluation and early-phase method validation of an analytical scheme for batch-consistency N-glycosylation analysis of recombinant produced glycoproteins.
Zietze, S., Müller, R. H., Brecht, R.
European Journal of Pharmaceutics and Biopharmaceutics. 2008, 68: 818–827
Azabrendanes V. Synthesis and reactions of stereoisomeric exo- and endo-5-aminomethylbicyclo[2.2.1]hept-2-ene–based ureas.
Lilija I. Kasyan, Andrey O. Kasyan, Igor N. Tarabara, Sergiy I. Okovytyy, Elena A. Golodayeva, Andrey V. Tokar, Yevgeniy Podolyan
Central European Journal of Chemistry. 6(2) 2008: 161–174
2007
An Avian Designer Cell Line for Vaccine Manufacture
Jordan, I., Vos, A., Neubert, A., Sandig, V.
BioWorld Europe. 03–2007
Oligomerization and Transglutaminase Crosslinking of the Cystatin CRES in theMouse Epididymal Lumen: Potential Mechanism of the extracellular Quality Control
von Horsten, H. H., Johnson, S. S., SanFrancisco, S. K., Hastert, M. C., Whelly, S.M., Cornwall, G. A.
Journal of Biological Chemistry. 2007, 282(45): 32912–23
Extracellular quality control in the epidermis
Cornwall, G.A.; von Horsten H.H.; Swartz, D.; Johnson, S.; Chau, K.; Whelly, S.
Asian Journal of Andrology. 2007 Jul, 9(4): 500–7
Physical and biological properties of barium cross-linked alginate membranes
Zimmermann H., Wählisch F., Baier C., Westhoff M., Reuss R., Zimmermann D., Behringer M., Ehrhardt F., Katsen-Globa A., Giese C., Marx U., Sukhorukov V., Vásquez J., Jakob P., Shirley S., Zimmermann U.
Biomaterials 28. 2007, 1327–1345
Novel Bioreactors for Fragile Glycoproteins
Langhammer S., Brecht R., Marx U.
GEN. 2007, January 1: 34–35
Why Is Human Tissue Culture Important to Drug Discovery?
Marx U.
In: Marx and Sandig: Drug Testing In Vitro – Breakthroughs and Trends in Cell Culture Technology, Wiley-VCH Verlag GmbH & Co. KgaA. 2007.
Overview on Bioreactor Design, Prototyping and in Process Controls for Reproducible Three Dimensional Tissue Culture.
Pörtner R., Giese C.
In: Marx and Sandig: Drug Testing In Vitro – Breakthroughs and Trends in Cell Culture Technology, Wiley-VCH Verlag GmbH & Co. KgaA. 2007.
Development of Human Designer Cell Lines to Enable Sustainable Supply of Differentiated Human Cells.
Sandig V. and Jordan I.
In: Marx and Sandig: Drug Testing In Vitro – Breakthroughs and Trends in Cell Culture Technology,
2006
A Human Lymph Node In Vitro – Challenges and Progress
Giese C., Demmler C.D., Ammer R., Hartmann S., Lubitz A., Miller L., Müller R. and Marx U.
Journal of Artificial Organs. 2006, 30(10):803–808
Three-Dimensional Characterization of Cell Clusters Using Synchroton-Radiation-Based Micro-Computed Tomography
Müller B., Riedel M., Thurner P. J.
Microsc. Microanal. 2006, 12. 97–105
2005
Alternative Strategies and New Cell Lines for High-level Production of Biopharmaceuticals
Rose, T.; Winkler, K.; Brundke, E.; Jordan, I.; Sandig, V.
In: Knäblein: Modern Biopharmaceuticals, Wiley-VCH. 2005. 761-778
Development and Assessment of Human Adenovirus Type 11 as a Gene Transfer Vector
Stone, D.; Ni, S.; Li, Z:Y:, Gaggar, A.; diPaolo, N., Feng, Q.; Sandig, V.; Lieber, A.
Journal of Virology. 2005. April. 5090-5104
Boosting Mammalian Cell-line Manufacturing Pilot Plant – A Case Report
Brecht, R.; Sandig, V.; Marx, U.; Riedel, M.; Koch., S.
BioPharm International. 2005. Vol. 18. No. 7.
Mammalian cells
Sandig, V.; Rose, Th.; Winkler, K.; Brecht; R.
In: G. Gelissen: Production of recombinant proteins. Wiley-VCH. 2005. 233-252.
2004
Linker peptide and affinity tag for detection and purification of single-chain Fv fragments
Küttner G., Giessmann E., Wessner H., Scholz C., Reinhardt D., Winkler K., Marx U., Höhne W.
Biotechniques. 2004 May, 36(5):864-870
Genome Size and Structure Determine Efficiency of Postinternalizytion Steps and Gene Transfer of Capsid-Modified Adenovirus Vectors in a Cell-Type-Specific Manner
Shayakhmetov, D.M., Li Z.Y., Gaggar, A., Gharwan, H., Ternovoi, V., Sandig, V., Lieber, A.
Journal of Virology. 2004 Sept, 10009–10022
2003
Intracellular transport of plant toxins ricin and viscumin from different plasma membrane sites
Moisenovich M., Agapov I., Marx U., Bereiter-Hahn J., Tonevitsky A.
Arzneimittelforschung. 2003, 53(6): 470–475
Novel B-ring modified allocolchicinoids of the NCME series: design, synthesis, antimicrotubule activity and cytotoxicity
Bergemann S., Brecht R., Buttner F., Guenard D., Gust R., Seitz G., Stubbs M.T., Thoret S.
Bioorg. Med. Chem. 2003 Apr 3. 11(7):1269–1281
The complete nucleotide sequence, genome organization, and orign of human adenovirus type11
Stone D., Furthmann A., Sandig, V., Lieber, A.
Virology. 2003 Apr 25. 309(1): 152–165
2002
Anti-human CD4 induces peripheral tolerance in a human CD4+, murine CD4-, HLA-DR+ advanced transgenic mouse model
Laub, R.; Brecht, R.; Dorsch, M.; Valey, U.; Wenk, K., Emmrich, F.
J Immunol. 2002 Sep 15. 169 (6): 2947–2955
Comparision between the mechanisms of action of plant toxins ricin and viscumin on the stage of intracellular dissociation
Tonevitsky, A.; Agapov, I.; Chelnokova, O.; Moisenovich, M.; Marx, U.
Arzneimittelforschung. 2002. 52(6): 500–505
Detection of isolated mistletoe lectin chains in plant extracts
Tonevitsky, A.G.; Marx, U.; Agapov, I.; Moisenovich, M.
Arzneimittelforschung. 2002. 52(1): 67–71
2001
Impact of nanometer-scale roughness on contract-angle hysteresis and globulin adsorption
Müller, B.; Riedel, M.; Michel, R.; dePaul, S.M.; Hofer, R.; Heger, D.; Grützmacher, D.
J. Vac. Sci. Technol. 2001. Sept/Oct. B 19(5)
Protein adsorbtion and monocyte activation on germanium nanopyramides
Riedel, M.; Müller, B.; Wintermantel, E.
Biomaterials. 2001. 22, 2307–2316
An improved helper-dependent adenoviral vector allows persistent gene expression after intramuscular delivery and overcomes preexisting immunity to adenovirus
Maione, D.; dellaRocco, C.; Gianetti, P.; dÁrrigo, R.; Liberatoscoli, L.; Franlin, LL; Sandig, V.; Ciliberto, G.; laconica, N.; Savino, R.
PNAS. 2001. May 22. vol.98. no.11, 5986–5992
The impact of nanometer – scale roughness on contact – angle hysteresis and globulin adsorption
Müller, B.; Riedel, M.; Michel, R.; De Paul, S.M.; Hofer, R.; Heger, D.; Grützmacher, D.
J. Vacuum Sci. Technol. 2001. B 19 (5) 1715–1720