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Therapeutic Proteins/Antibodies

Therapeutic Proteins/Antibodies

Therapeutic proteins are proteins that are engineered in the laboratory for pharmaceutical use. Insulin was the first therapeutic protein to be introduced to treat diabetes in the 1920s. 

Due to recombinant DNA-technology proteins can be generated in specific host cells (e. g. bacteria, yeast or mammalian cells) under defined conditions. Depending on the requirements of the protein the production host has to be chosen carefully. Mammalian cells are the main host of choice because their posttranslational modifications such as glycosylation and sialylation have the biggest impact on the protein’s pharmacokinetics and efficiency. 

Protein-based therapies are used for example in the treatment of:

  • Cancer
  • Infectious Diseases
  • Hemophilia
  • Anemia
  • Multiple Sclerosis
  • Hepatitis B/C

Therapeutic proteins permit an individualized treatment approach by supporting a specifically targeted therapeutic process by compensating the deficiency of an essential protein.

The fastest growing class of therapeutic proteins is antibodies. On the one hand they support the immune response and on the other hand they can induce the accumulation of therapeutic agents at a tumor site through conjugation/fusion. Antibodies are not only a useful tool in the treatment of cancer but also in the treatment of auto-immune disease.

Specific to the product we at ProBioGen can select between different starter cell lines for the development process of pharmaceutical cell lines with the aim to achieve the highest quality of the product.

Learn more about cell line development