A fully integrated analytical team is the key to success and facilitates the entire cell line development workflow. Critical product attributes are identified and controlled right from the start, which enables the selection of high-quality clones in accordance with QbD principles (quality by design) for manufacturing. State-of-the-art equipment and methods include mass spectrometry, HPLC, capillary electrophoresis for size and charge variants, DNA sequencing (Oxford Nanopore Technologies), and digital PCR for genetic characterization.
