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TECHNOLOGIES FOR VIRAL VECTORS & VACCINES

Designer Cell Line AGE1.CR.plX®

If you're looking for a high performing avian cell line for vaccine viruses, our immortalized and stable proliferating avian cell line AGE1.CR.pIX® is your ideal solution.  

The cell line is fully developed under GMP-compliance and is completely documented. 

IN A NUTSHELL

Highly Permissive Designer Cell Line for Vaccine Viruses

ProBioGen has designed and developed an immortalized and stable proliferating avian cell line, the AGE1.CR.pIX®, that is highly permissive for a variety of different vaccine viruses, including poxvirus vectors. The cell line development, from egg to generation of cell banks, was performed completely under GMP-compliance at ProBioGen and has been fully documented. We developed a chemically-defined medium that allows optimal growth. The cell line is available both as an adherent and as a suspension cell line and is well known in the academic and industrial community. 

AGE1
ProBioGen Eppis

Key Features of AGE1.CR.PIX®

Fully-documented and free of adventitious agents, including active endogenous retroviruses 

Robust and fully-scalable proliferation in suspension culture for different bioreactor systems in chemically-defined media  

Highly susceptible to a range of viruses, such as pox-, adeno-, orthomyxo-, rhabdo-, paramyxo- and togaviruses  

Readily transferable for flexible, local GMP manufacturing with a small footprint

 

Cost-saving over manufacturing in CEFs

HOW WE WORK
Suspension USP and Culture Media
Cell Banks and Safety
AGE1 Workhorse
Use Cases

Our Promise To You

Asset 27-1
 
Highly Permissive Cell Line 
  • For a large variety of viruses 
  • For both human and animal vaccine production, and vectors

 

 

Growth Graph-Blue
 
Highly Evolved Package
  • Chemically-defined media optimized for cell line, also in powder format 
  • Adherent and suspension cultivation possible 
  • Comprehensive technology transfer for production at desired scale and purpose 
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Full Documentation
  • From origin, treatments, passaging and raw materials; we confirm that MCBs/WCBs are free of adventitious agents and any reverse transcriptase activity  
  • Fully GMP compliant (EU and US guidelines) 

 

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