Your Reliable and Agile Partner for Top Results

ProBioGen AG is a renowned Contract Development and Manufacturing Organization (CDMO) and technology provider. We perform cell line engineering, process development, and GMP manufacturing of biopharmaceuticals for clients in biotech and pharma. We offer proprietary innovative technologies for optimized biopharmaceutical manufacturing and analysis. ProBioGen also provides process development services and manufacturing technologies for viral vaccines.

Our additional new building houses 1000 L single-use bioreactor capacity to keep up with the ever-increasing demand from our clients. A second 1000 L single-use bioreactor is coming soon.

With over 25 years of experience in animal cell culture, combined with innovative scientific excellence and a strong intellectual property base, we cover the drug development value chain up to clinical phase III.

Our History

1994 – ProBioGen founded as a diagnostic company

2000 – Strategic shift towards therapeutic protein contract development and GMP manufacturing

2001 – Cell line development platform established

2002 – Manufacturing authorization granted, using single-use bioreactors right from the beginning

2003 – First client designer cell line developed

2005 – More than 15 patent families granted

2008 – First commercial license for AGE1.CR duck cell line

2010 – Strategic Investor: Minapharm Pharmaceuticals

2011 – First commercial license given for GlymaxX® ADCC enhancement technology

2013 – First product produced with ProBioGen CHO cell line entered the market

2016 – First product produced on AGE1.CR® duck cell line entered the market

2017 – More than 400 stable cell lines developed

2019 – Two facilities in Berlin-Weißensee

2019 – Launch of ProBioGen's DirectedLuck™ Transposase

2020 – Capacity increase with 1000L single-use bioreactor

2021 – Incorporation of the subsidiary MiGenTra GmbH




Global Customer Base

We are the partner of choice for biopharmaceutical companies relying on high quality cell line development and manufacturing capabilities. Our partners value our outstanding service quality, combined with variable project and deal structures, our quick responses and our flexibility.

Our clients benefit from custom-tailored projects designed to minimize development risks and ensure a successful outcome. Our experienced and flexible team of scientists, engineers, and technicians draws its motivation from the success of our clients’ projects. We are a reliable and agile partner in developing our clients’ products to the benefit of patients worldwide.

Our new building was recently refurbished to house 1000L single-use bioreactor lines to keep up with the ever-increasing demand from our clients.


Since its foundation in 1994, ProBioGen has evolved from a research-based company into a fully grown, commercially successful biopharmaceutical organization. Apart from its cutting-edge, market-driven technologies, its success also lies in the dedication of its staff and, above all, the experience of its management team that brings a wealth of knowledge in the different areas of our day-to-day operations and an in-depth understanding of the trends and needs of the industry.

Dr. Lutz Hilbrich, Chief Executive Officer

Dr. Lutz Hilbrich holds a Medical Degree from the Julius-Maximilians University, Wuerzburg, Germany and an MBA from Stern School of Business at NYU, USA. Before joining ProBioGen in June 2020 he was the Head of the Biosimilars Platform China for Sanofi and was previously second in command for the Biosimilars Business Unit at Boehriger Ingelheim GmbH, Germany.

He is experienced in CMC-, Pre-clinical -and Clinical Development but also in Business Development and Market Access Strategies. Besides serving on a couple of organizational committees for international conferences on Biologics and Biosimilars, he sits on the Biosimilar Advisory Board of the American Conference Institute (ACI).

Dr. Volker Sandig, Chief Scientific Officer
Dr. Volker Sandig, Chief Scientific Officer

Volker Sandig initiated ProBioGen’s cell line development program in 2000 resulting in the unique Cell Line platform CHO.RiGHT® and development of the CHO-Freedom Kit with LTC (now Thermo-Fisher). He directs expansion of the company's technology portfolio, manages its broad intellectual property base and is inventor of multiple technologies including GlymaxX®. In addition, his work aims at modernizing manufacture of viral vaccines and gene therapy vectors through customized design of new cell lines and innovative processes to support a wide range of human and animal viruses. Prior to joining ProBioGen, he lead a research group at Merck Research Laboratories, USA, focusing on the development of manufacturing systems for gutless adenoviruses and vectored vaccines. Volker Sandig holds a medical degree and received his doctorate in Molecular Biology from the Humboldt University, Berlin.

Dr. Gabriele Schneider, Chief Business Officer
Dr. Gabriele Schneider, Chief Business Officer

Chief Business Officer since November 2017 following 10 years as Vice President Business Development. Gabriele is responsible for commercial and business strategy and manages all activities pertaining to business development. She has an established track record of building strong and lasting relationships with clients and partners worldwide. She joined the biotech industry in 2000 as Project Manager at Kelman GmbH and was consulting small biotech companies before joining ProBioGen in 2003. Gabriele holds a master’s degree in political science from Johann Wolfgang Goethe University Frankfurt and a doctorate from Humboldt University Berlin, Germany.

Dr. René Brecht, VP Process Science & Manufacturing
Dr. René Brecht, Chief Operations Officer

Dr. René Brecht joined ProBioGen in 2002 and is Chief Operations Officer. René Brecht is responsible for process development for recombinant proteins and antibodies as well as for fusion proteins, up to GMP manufacturing of clinical materials. Prior to joining ProBioGen, he held a position as Research Scientist at the University of Leipzig, where he was responsible for pre-clinical and GMP process development of monoclonal antibodies and antibody fragments for therapeutic and diagnostic purposes. René Brecht received his doctorate in Pharmaceutical Chemistry from the University of Marburg on natural occurring anticancer compounds.

Andrea Hauptmann, VP Finance & Administration
Andrea Hauptmann, Chief Financial Officer

Vice President Finance & Administration at ProBioGen since 2015 and Chief Financial Officer since 2021. Andrea Hauptmann has been responsible for financial reporting, controlling, funding and cash management, risk management, human resources and administration since 2011. Before joining ProBioGen in 2009, she held a number of key financial management positions in the service and real estate sector. Andrea Hauptmann holds a diploma in economics. She was granted power of attorney in 2009.


The remarkable scientific progress in the last two decades has given rise to the development of new technologies at an unprecedented pace. We continuously screen the market and leverage our global network to identify and evaluate potential partners. Our partnerships are collaborative and target specific results, with a strong focus on value for our end customers.

Thermo Fisher Scientific

We engineered the Freedom™ CHO-S™ Kit platform, which enables cost-and-time-efficient stable cell line development for research and commercial purposes, in close collaboration with Thermo Fisher Scientific. The kit is available via Thermo Fisher Scientific.

Boehringer Ingelheim

Boehringer Ingelheim has a non-exclusive license for ProBioGen’s proprietary GlymaxX® ADCC enhancement technology (Antibody-Dependent Cell-Mediated Cytotoxicity). Under this license, Boehringer Ingelheim applies GlymaxX for third parties from its global contract manufacturing platform as well as to its own development candidates, to produce antibodies with enhanced ADCC potency.


Our customer range is extensive; some of our key customers and selected references are:


Please feel free to contact us regarding our references. We are more than happy to connect you with relevant clients on an individual basis.

For further information please contact us at

Quality Management

The high quality of ProBioGen’s products relies on the synergetic improvement of each individual process step. Our quality management system is based on standard DIN EN ISO 9001:2015 and specifically tailored to serve our client's individual requirements. ProBioGen holds a manufacturing authorization for GMP compliant manufacturing and batch release of biotechnological drug substances.

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