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TECHNOLOGIES FOR PROTEINS & ANTIBODIES

DirectedLuck® Transposase System for Proteins and Antibodies

Advance your cell line development with a cutting-edge transposase system that provides the highest titer and expression stability. DirectedLuck® offers superior product quality for complex biologics, such as bi-/multi-specific antibodies, while also accelerating time to clinic! 

IN A NUTSHELL

Transposase as Expression System for Biologics

DirectedLuck® is a highly efficient gene delivery and expression system based on epigenetic targeting and carefully designed transposase and transposons. Our technology delivers transposons specifically to integration sites with the highest transcriptional activity. This results in elevated titers and ensures stability. Easy adjustment of gene dosage enables the highest possible heterodimer rates for bi-/multi-specific antibody formats. The technology reduces effort and accelerates time to clinic. 

Directed.Luck Transposase for Proteins and Antibodies

Key Features of DirectedLuck®

Epigenetic targeting of best genomic integration sites

Thoroughly designed transposase and transposons

Highest level of robustness reported from licensees 

Elevated titer and outstanding stability for pools and clones 

Hundreds of producer cell lines generated at ProBioGen or in licensee labs
Exceptional product quality for bi-/multi-specific antibody formats 
Royalty-free
Directed.Luck Epigenetic Targeting
HOW IT WORKS

Stable Pools for Manufacturing

The system is extremely robust. Pools, generated within a few days, are highly representative of later clones. Productivity is homogeneous between bulk pools. Since the expression and product quality of these pools are also remarkably stable, they are well suited for large-scale production, e. g. of material for TOX studies. 

Versatile Transposase Compatibility

The DirectedLuck® transposase is compatible with additional genetic elements in standard expression vector design and can be used with any host cell line from different species and tissue origin.

USE CASES

When to Use DirectedLuck®

Robust production of larger quantities of R&D material with stable pools

Generation of stable pools for rapid manufacturing of TOX material
Cell line development for any type of simple and complex biologics  

Parallel development of pools and producer cell lines for multiple candidate variants 

Our Promise To You

Peak-Blue
 
Achieve Superior Titer and Stability with the Utmost Robustness  
  • Utilize epigenetics for targeting and integration at genomic sites with the highest levels of activity 
  • Superior genomic harbors and transposon elements provide the utmost robustness, titers, and stability


Success-Blue
 
Get Exceptional Product Quality

 

  • In complex biologics with multiple chains, these chains have to be balanced to achieve the highest content of the desired product 
  • As expression is copy number dependent, ratios of transposons used for individual protein chains can be flexibly adjusted to modulate product purity 
Asset 21
 
Take the Fast Path to Clinic
 
  • Streamline the entire cell line development workflow 
  • Highly productive and stable pools can be used for the manufacturing of TOX material 



Elevate Your Candidate With The Right Technology 

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