Cell Line Development Services for Proteins & Antibodies

Our cell line development services utilize our highly advanced DirectedLuck^® transposase and transposon, our optimized host cells, and our own chemically-defined process medium. All this shape our unique CHO.RiGHT^® platform. We use our CHO-DG44 strain, which has been selected and optimized for its fast growth, high genetic stability, and efficient metabolism. For molecules where distinctive product features (e. g. glycans) are required, we offer a wide range of pre-engineered hosts or other strains. And also: no license fees or strings attached!

In Collaborative Team Effort with Our Clients

We strongly embrace a partnership approach. This starts by listening very carefully to our clients to gain a deep understanding of the molecule and its properties and then adapting flexibly to their needs throughout the project. We anticipate risks, tackle challenges, and make adjustments in close cooperation with you.

Combining a Scientific Approach with Pragmatic Solutions

We gain a deep understanding of your molecule and use our scientific expertise to anticipate critical product features. Our fully integrated analytical and next generation sequencing teams ensure that scientists engage closely, which enables timely and accurate conclusions. Our passion for solving problems helps us arrive at pragmatic solutions in the shortest possible time. This makes us specialists when it comes to handling highly complex molecules such as multi chain formats.

With Smart Automation

Our modular automation concept offers unique flexibility. It allows an earlier analysis of critical product attributes for a larger number of clones. The output is clones with the highest quality level, higher titer, and a considerably accelerated workflow. On top of that, the system increases the throughput and enables parallel development of multiple molecule variants.

Leveraging Our Stellar Technologies

ProBioGen's DirectedLuck^® transposase technology delivers the highest productivity, stability, and product quality. This best-in-class transposase is designed to target specific epigenetic marks and facilitate transgene integration at highly active genomic sites.

GlymaxX^®, our outstanding afucosylation technology, also makes a real difference. Notably, it makes it possible to adjust any desired fucosylation level for the specific product.

Starting with Multiple Variants

Saving time and minimizing risk are good reasons to develop multiple molecule variants in parallel, without significantly increasing the timelines and costs. Perhaps you want to confirm manufacturability? Or maybe your last animal study is ongoing and you have not selected your final lead candidate yet? We have the experience and capacity to handle multiple molecule variants in parallel, even across the entire cell line development process. Our toolbox: a highly efficient expression system, fully-integrated product characterization, and smart automation.

Bulk Pools Ready for Manufacturing

Our transposase system delivers highly productive bulk pools. In these pools expression and product quality are extremely stable. In addition, their product quality features are predictive for clones. These bulk pools can be used for manufacturing at larger scale to produce material for development work or TOX studies. Such an approach relies on close interaction with the USP and DSP teams and greatly speeds time to clinic.